•Teitelbaum, S. L., and F. P.
Ross. "Genetic Regulation of Osteoclast Development and
Function.". Nat Rev Genet 4.8 (2003): 638-49. BONE$
•Binding
of RANKL to RANK leads to receptor trimerization. This is followed by the recruitment of adaptor molecules, including TRAF6, which interact with c-Src to stimulate the
PI-3K/Akt
axis, which regulates both the osteoclast (OC) cytoskeleton and apoptosis. The detailed pathways
that lead
to activation of the three MAPKs and the various components of the NF B complex are only partially defined. Important downstream regulators of osteoclast formation include c-Fos,
Fra-1 and
nuclear factor activated T cells c1 (NFATc1). ERKs, extracellular receptor kinases; JNK, jun kinase; NF B,
nuclear factor B; PI-3K, phosphatidylinositol 3 kinase; RANK, receptor activator of
NF B;
RANKL, RANK ligand; TRAF6, tumour necrosis factor receptor associated factor 6.
Voies de signalisation Rank (Receptor Activator of the NF kB ligand)
Binding of RANKL to RANK leads to receptor trimerization. This is followed by the recruitment of adaptor molecules, including TRAF6, which interact with c-Src to
stimulate the
PI-3K/Akt axis, which regulates both the osteoclast (OC) cytoskeleton and apoptosis. The detailed pathways
that
lead to activation of the three MAPKs and the various components of the NF B complex are only
partially defined.
Important downstream regulators of osteoclast formation include c-Fos, Fra-1 and nuclear factor activated T cells c1
(NFATc1). ERKs,
extracellular receptor kinases; JNK, jun kinase; NF B, nuclear factor B; PI-3K, phosphatidylinositol 3 kinase; RANK, receptor activator of NF B; RANKL, RANK ligand; TRAF6, tumour necrosis factor receptor associated factor 6.